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MIR4 Updates ‘Sabuk Clash’ to Determine the Most Powerful Clan


- Sabuk Clash, tournament style Castle Siege content between the King's clans of all servers
- Given the authority to manage Sabuk Castle territories, adjust taxes, and more upon becoming the Emperor's clan
- Check-in events that offer various items are held to celebrate the update of new content


(BUSINESS WIRE) -- Wemade’s blockbuster MMORPG MIR4 updated Sabuk Clash, clan vs. clan Castle Siege, on March 21st.

 “Sabuk Clash” is a tournament style Castle Siege content where King’s clans from all servers in each region gather in the Domination Server and fight to become the Emperor’s clan. Only Bicheon Castle King’s clans can participate. The winning clan then becomes the Emperor’s clan, which can collect taxes from the Kings of all servers in each region, adjust individual tax rates per server, and is given authority to manage the Sabuk Castle territory.

The first round begins on March 26th at 10 pm, and a new round will be held every week for a total of 3 rounds over 3 weeks. In the first round, a total of 16 clans fight to capture one of the 8 Monoliths placed in 8 areas, and the 8 winning clans advance to the next round. In the second round, 4 out of 8 clans advance to the next round. And out of the 4 clans in the final round, the one clan that succeeds in capturing the Monolith becomes the Emperor’s clan.

The winning clan receives 50,000 clan copper as a reward. The clan master of the winning clan becomes the Emperor and receives the authority to appoint positions, adjust tax rates, give prizes, and more. The Emperor also gets an Emperor-exclusive mount, Sabuk Destrier.

In addition, to celebrate the appointment of a new Emperor, all users in every server receive “Sabuk Emperor’s Common Royal Gift” the day after round 3 ends. The gift contains various items such as “Epic Dragon Oil of Blessing,” “Rare Dragonsteel Box” and more.

MIR4 is hosting two check-in events to celebrate the update of Sabuk Clash. First, the “Luckster’s Sabuk Clash 7-Day Cheer Check-in” event will give users Rare to Legendary “Luckster Potion Box” containing buff potions until April 3rd. Also, from March 27th to April 17th, “Epic Divine Dragon’s Dragon Artifact Enhancement Stone,” “Rare Mystical Piece Box,” and more items required for growth can be obtained from “The Age of War 14-Day Check-in” event.

Meanwhile, the “Darkness 14-day Check-in Event” and the “Divine Dragon’s Blessing Event” will be held until April 3rd to celebrate the update of a new class, Darkist.

From My Battle, To Our War! Detailed information on MIR4 can be found on the official website.


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Wemade Co., Ltd. (112040: KOSDAQ)
Jennifer Jung, PR Manager


Visa Defines New Era of How Money Travels Abroad

SAN FRANCISCO - Wednesday, 22. March 2023 AETOSWire Print 

Money movement across borders can be fragmented, slow and inefficient; New Visa research reveals consumers see the future as digital

(BUSINESS WIRE) -- Remittances are not only a lifeline for millions of migrant workers and their families, they are also vitally important for the prosperity of many developing economies around the world. As the amount of global remittance inflows continues to reach new records1, 53% of surveyed consumers are turning to digital apps to send and receive funds around the world.

Visa today unveiled its “Money Travels: 2023 Digital Remittances Adoption” research report, a survey of over 14,000 consumers across ten countries, revealing that digital remittances are quickly becoming the most popular way to move money internationally, when compared to going to a physical bank or branch (34%); sending cash, checks or money orders by mail (12%); or giving money to another person who is traveling to their home country (11%).

In conjunction with the study, Visa launched “Money Travels,” a new podcast series unearthing how payment-related topics unfold differently in various places around the world and highlighting the stories of real people, payment experts and partners.

“Fast, easy and secure payments can make a profound difference to families, communities and economies around the world,” said Ruben Salazar, Global Head of Visa Direct. “This new research shows incredible acceleration of digital payments, but there is still more the industry can do to bring streamlined remittances within reach for more migrant workers and their families who rely on these lifeline payments to do everything from pay for food, education, or even unforeseen medical costs.”

The Money Travels: 2023 Digital Remittances Adoption study examines how consumers send money abroad, diving into the rates, methods, and reasons for sending and receiving these lifeline payments. Highlights include:

Digital remittances are the preferred method amongst surveyed consumers across all surveyed countries. 60-70% of surveyed remittance users across North America have used an app-based digital payment method to send/receive money internationally, whereas only 10-15% of surveyed U.S. remittance users rely on cash, checks, and money orders. Similarly, sending money through digital apps is the most popular method for 69% and 65% of surveyed consumers in Saudi Arabia and the United Arab Emirates, respectively, compared to digital from a physical location, cash, or check.

Adoption of app-based digital payments is high, with low barriers to usage. Three-quarters of surveyed remittance senders in Mexico and Peru have used app-based digital payment methods, while two-thirds of recipients have used an app. Additionally, in Europe, 62-67% of surveyed consumers across France and Poland who have sent international remittances have used digital methods.

Remitter pain points include but are not limited to high fees and issues with calculating exchange rates. In total, 38% of surveyed consumers on the send side in the United Arab Emirates report fees being too high when sending digital remittances, and 37% of surveyed consumers on the send side in Singapore report issues with calculating the exchange rates.

App-based digital payments are considered the most secure method by a strong proportion of remittance users across countries. In Singapore, a key remittance country on the send side, three out of five (61%) surveyed consumers reported using digital-only means for sending money internationally thanks to ease of use and security (53%).

Rates of sending and receiving remittances vary widely by country. Of the countries surveyed, Poland, Mexico, Peru and the Philippines receive remittances at higher rates than sending them. France and Singapore see higher send rates.

Sending more money, more often, is easier than ever. Over half of those who have sent money internationally do so about once per month or more often in the United Arab Emirates (71%), Saudi Arabia (64%) and the Philippines (48%). Among those who have received money 80% do so at least a few times per year in Saudi Arabia, followed by the Philippines (77%), and Mexico (72%).

Visa works in collaboration with global remitters such as Brightwell, Maya Philippines, MoneyGram, Paysend, Remitly, Western Union and Xoom to help enable efficient money movement through digitized remittances. “One of our visions for Visa Direct is to create new opportunities for financial inclusion and wealth building by helping to simplify cross-border payments and streamline the way money travels,” continued Ruben Salazar.

A new “The Connective Power of Remittances” Nonstop Guide explores the rise of digital remittances, the tales behind these types of payments and how the digital revolution is helping streamline remittance payments. For more information about Visa Direct, please visit:

Survey Methodology

This survey was conducted by Morning Consult during December 14-28, 2022 among a sample of 14,000+remittance senders and receivers across the U.S., Canada, Mexico, Peru, France, Poland, Philippines, Singapore, United Arab Emirates, and Saudi Arabia. The interviews were conducted online. Within each country, survey respondents are weighted based on census estimates for age, race/ethnicity, gender, education, and region.

About Visa Inc.

Visa (NYSE: V) is a world leader in digital payments, facilitating payments transactions between consumers, merchants, financial institutions and government entities across more than 200 countries and territories. Our mission is to connect the world through the most innovative, convenient, reliable and secure payments network, enabling individuals, businesses and economies to thrive. We believe that economies that include everyone everywhere, uplift everyone everywhere and see access as foundational to the future of money movement. Learn more at

1 World Bank Personal remittances, received (current US$)


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(650) 418-0352
Tierney Deggelman

Collaborative Efforts Bear Fruit as Advansys and Celfocus Celebrate Successful First Milestones in Egypt

Cairo, Egypt - Wednesday, 22. March 2023


Advansys, a global technology solutions provider, has achieved a significant milestone with the successful establishment of a world-class development center for Celfocus in Egypt. The two companies celebrated the successful milestone in an event that was attended by distinguished guests, including the Portuguese ambassador in Egypt and the CEO of the Information Technology Industry Development Agency (ITIDA) in Egypt.

Advansys' expertise in building development centers and providing exceptional tech talent for outsourcing has played a crucial role in making this project a reality. The center is equipped with state-of-the-art facilities and staffed with highly skilled and experienced tech talent. The partnership has created numerous job opportunities for Egyptian tech talent, reinforcing Egypt’s position as a leading hub for digital and high-end services.

"We are thrilled to celebrate this significant achievement with our partner, Celfocus," said Ahmed El Moghazy, CEO of Advansys. "Our collaboration has been instrumental in building a world-class development center in Egypt, and we are proud to have played a part in the country's emerging tech scene. This project has showcased Advansys' capabilities and expertise, and we look forward to continuing to deliver exceptional services to our clients in Egypt and beyond."

Celfocus COO, Álvaro José Ferreira, added; “Celfocus found in Advansys a fast and professional response for our need to implement a technology development center in Egypt. We are very excited with the results already achieved and look forward to expanding the capacity of our Egypt Delivery Center in the coming months.”

"This significant milestone with Celfocus, achieved ahead-of-plan, strengthens our partnership, and proves that collective efforts - from both teams - always delivers a unique experience." said Sharaf El-Din Mohamed, Business Solution Director, Advansys. Advansys delivers exceptional customer experience and cost-efficient solutions through its extensive North American, European, and Middle Eastern market experience and innovative business models.

The successful completion of the project is in line with Egypt's goal of becoming a top outsourcing destination.  This milestone is not only a win for Advansys and Celfocus but also for Egypt's tech industry, as it enables the creation of job opportunities for Egyptian tech. talents. This accomplishment showcases the country's potential as an outsourcing hub, attracting potential clients seeking to establish development centers or outsourcing capabilities. With Advansys' proven track expertise, the company is well-positioned to help clients to successfully establish development centers and outsourcing capabilities in Egypt and beyond.

About Advansys:

Advansys is a dynamic international solutions provider, passionate about building smart, modular, comprehensive, and sustainable solutions for today's world of business. Advansys offers tailored solutions in different areas such as strategic outsourcing, business automation, digital transformation, and industrial automation.

For more information:

About Celfocus:

Celfocus is a European high-tech system integrator providing professional services focused on the analytics & cognitive domains. The company helps clients undergo their business evolution, providing technological solutions to extract value from data through digital transformation.

Marwa Mamdouh


Waters’ New Battery Cycler Microcalorimeter Solution Accelerates Real-World Testing from Months to Weeks

News Summary:

New Battery Cycler Microcalorimeter Solution collects up to six times more data than other commercially available calorimeters.i
Integrated real-time data analysis accelerates validation of battery safety, quality, and performance testing by up to 75%.ii
Up to 12 batteries can be tested simultaneously for charge-discharge and thermal testing to design experiments in multiple configurations.

(BUSINESS WIRE) -- PITTCON 2023 — Waters Corporation (NYSE:WAT) today announced a new Battery Cycler Microcalorimeter Solution from its TA Instruments™ Division for high-resolution characterization of battery cells. The instrument and software combination enables non-destructive testing under real-world operating conditions and significantly reduces experiment time from months to weeks, while providing decisive insights for greater battery efficiency, safety, and stability.

“Innovations like our in-operando Battery Cycler Microcalorimeter Solution are revolutionary for the future of battery R&D,” says Jianqing Bennett, Waters Corporation Senior Vice President of the TA Instruments Division. “It significantly reduces testing time by up to 75%, while helping researchers learn more about how batteries and their materials behave and change under both thermal and electrochemical conditions. The precise data it provides scientists is essential to help ensure battery performance and safety.”

The solution combines the TA Instruments high-resolution TAM IV Isothermal Microcalorimeter and integrated TAM Assistant Software platform with a BioLogic VSP-300 potentiostat (battery research instrument) to deliver accurate, rapid detection of parasitic heat reactions, an early indicator of battery efficiency. The Battery Cycler Microcalorimeter supports testing of three common battery types – coin, pouch, and 18650 cylindrical – for charge/discharge and thermal testing in parallel. It can maximize researcher efficiency with support for testing and data collection of up to 12 coin-sized batteries simultaneously – six times more than competitive offerings.

The easy-to-read TAM Assistant Software reduces technical barriers to training while enabling researchers to define parameters and plotting options, as well as interpret aggregated data to make informed decisions for their experimental or process strategy. This novel solution enables researchers to better predict electrolyte calendar life, which aids in the development of new electrolytes and electrode materials.

See Waters’ Battery and Polymer Innovations at PittCon 2023

At PittCon Booth #2406, the TA Instruments Division will showcase a full suite of innovative instruments, accessories, and software designed to advance research and development for both battery and sustainable polymer designs. Attendees can see demos and learn more about new solutions for simplifying, automating, and accelerating polymer melt rheology testing with the Discovery Hybrid Rheometer Auto-Trim Accessory. Also in the booth will be the Powder Rheology Accessory, which accelerates product development and process optimization of powder materials, helping to characterize the behavior of raw materials or new formulations during storage, dispensing, processing, and end-use.

Additional Resources

Learn more about the Battery Cycler Microcalorimeter Solution

Visit the Waters online press kit for PittCon ’23 news and product images

Follow and connect with Waters via LinkedIn, Twitter, and Facebook

About Waters Corporation (

Waters Corporation (NYSE:WAT), a global leader in analytical instruments and software, has pioneered chromatography, mass spectrometry, and thermal analysis innovations serving the life, materials, and food sciences for more than 60 years. With more than 8,200 employees worldwide, Waters operates directly in more than 35 countries, including 14 manufacturing facilities, and with products available in more than 100 countries.

Waters and TA Instruments are trademarks of Waters Corporation.

i Based on Waters/TA Instruments analysis of publicly available information from competitor portfolios. The TAM IV can test and gather data for up to 12-coin cell batteries simultaneously, versus a maximum of 2 in competitor products.

ii Based on Waters/TA Instruments analysis of traditional electrolyte screening methods = 2 months of testing, but this ranges from 2-4 months on average. Waters/TA Instruments internal data shows typical experiment time for full cycle parasitics measurement using Battery Cycler Microcalorimeter Solution is ~ 2 weeks. Further time savings can be realized when narrowing to a specific voltage range (i.e., 4 to 4.2 V).


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Janice Foley
Senior Manager, Public Relations
Waters Corporation
+1 617-823-5555

Ceres Collaborates with Bosch and Linde Engineering on a 1MW Green Hydrogen Demonstration


  • Assessment of Ceres’ solid oxide electrolysis (SOEC) technology for use on an industrial scale
  • Testing of lower-cost green hydrogen production with a megawatt system
  • Two-year trial to take place at Bosch’s Stuttgart site in Germany


(BUSINESS WIRE) -- Ceres Power Holdings plc, a global leader in fuel cell and electrochemical technology, has signed contracts with Linde Engineering and Robert Bosch GmbH (“Bosch”) to start a collaboration to validate the performance, cost, and operational functionality of its SOEC technology.

The companies plan to prepare a two-year demonstration of a one-megawatt SOEC system, starting in 2024 and to be located at a Bosch site in Stuttgart, Germany. Its aim is to showcase that the technology provides a highly efficient pathway to low-cost green hydrogen, which has a significant role to play in harder-to-decarbonise industrial sectors.

Ceres has committed £100 million for the development of its SOEC technology. Its first 100kW electrolyser module is currently on test and initial results are providing confidence that this technology can deliver green hydrogen at <40kWh/kg, around 25% more efficiently than incumbent lower temperature technologies.

Linde Engineering has world-leading capabilities in industrial process engineering of chemical plants and a global footprint in industrial facilities. Coupled with Bosch’s significant expertise in product industrialisation and mass manufacturing, the companies are aiming to evaluate and qualify SOEC technology for large scale industrial applications.

The SOEC programme builds on Bosch’s experience of Ceres’ solid oxide fuel technology (SOFC) and the technology shares the same material sets, manufacturing process, equipment, and stack design. The demonstration represents an important validation of SOEC at a system level, which is a relevant basis for potential commercialisation.

Phil Caldwell, Chief Executive Officer of Ceres, commented: “The vision for our partnership with Linde Engineering and Bosch is to set a new industry standard for solid oxide electrolysers, leading to widespread adoption in industrial applications. By combining Ceres’ unique technology, Bosch’s strength in scaled manufacturing and Linde Engineering’s solid expertise hydrogen production, processing, distribution and storage, we will establish a partnership that can make our technology even more competitive and prepare it for mass market adoption at scale.”

For further information visit


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Ceres Power Holdings plc
Elizabeth Skerritt
Tel: +44(0)7932 023 283


Campbell Lutyens and J.P. Morgan announce strategic collaboration in the secondary advisory market

(BUSINESS WIRE) -- Campbell Lutyens and J.P. Morgan are pleased to announce the establishment of a strategic collaboration to jointly offer their advisory services on single-asset and concentrated multi-asset continuation fund secondary transactions. The offering will enable clients to benefit from Campbell Lutyens’ and J.P. Morgan’s global, market leading secondary and Investment banking advisory practices, respectively.

The proposition combines J.P. Morgan’s global top-tier investment banking services with Campbell Lutyens’ leading global placement and secondary advisory platform, creating a best-in-class global offering for single-asset and concentrated multi-asset continuation funds. It will be available for clients across all regions and sectors in which Campbell Lutyens and J.P. Morgan both operate. The offering provides access to Campbell Lutyens’ secondaries expertise focused on fund structuring and capital raising from secondaries and institutional investors along with J.P. Morgan’s M&A services, industry expertise and capital raising capabilities.

“We are delighted to be working with J.P. Morgan and believe that our combined capabilities and experience offer a compelling proposition in the secondary advisor market,” said Immanuel Rubin, head of European and Asia Pacific secondary advisory and Gerald Cooper, head of North American secondary advisory at Campbell Lutyens. “Our clients will now have the option to benefit from the resources and expertise of both of our franchises when seeking to complete these types of complex secondary transactions.”

“The secondaries market is a fast growing and important market for our private equity and infrastructure clients globally,” said Anu Aiyengar, Global Head of Mergers & Acquisitions at J.P. Morgan. “Through our unique collaboration and complementary skillsets, we will be able to provide our clients with a comprehensive and differentiated service offering for their continuation fund projects.”

Campbell Lutyens has advised on more than US$125 billion of secondary transaction volume, completing over 290 successful secondary portfolio sales and advisory mandates. Its secondary advisory practice includes more than 50 professionals across North America, Europe and Asia Pacific.

About Campbell Lutyens

Campbell Lutyens is a global and independent private markets advisor, providing fund placement, secondary advisory and GP capital advisory services to leading fund managers and investors. With specialist knowledge in private equity, infrastructure, private credit and sustainable investing, the firm has a team of 220 operating from offices in London, Paris, New York, Los Angeles, Chicago, Charlotte, Hong Kong and Singapore.

About J.P. Morgan

J.P. Morgan’s Corporate & Investment Bank is a global leader across banking, markets and securities services. The world’s most important corporations, governments and institutions entrust us with their business in more than 100 countries. With $28.6 trillion of assets under custody and $649.7 billion in deposits, the Corporate & Investment Bank provides strategic advice, raises capital, manages risk and extends liquidity in markets around the world. Further information about J.P. Morgan is available at


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For further information, please contact:

Campbell Lutyens:
Aarti Iyer
Head of Communications
Tel: +1 647 619 1076

J.P. Morgan:
Patrick Burton
Head of Marketing & Communications, EMEA
Tel: +44 20 7134 9041

Cirium Launches the First Airline Routes Tool Based on Satellite-Based Flight Tracking

In an industry first, the Airline Routes tool analyzes an airline’s routes using satellite-based flight tracking data to identify actual flights flown by aircraft type
Businesses can identify aircraft demand and where airlines are growing or reducing their network to factor development opportunities or risks into decision making
An analysis using the tool shows how Indian low-cost-carrier IndiGo flew 172 flights between Delhi and Kathmandu using Airbus A320s this January compared with no flights in January 2022, and five times the flights with A320s between Dubai and Ahmedabad year-over-year

(BUSINESS WIRE) -- Cirium, the aviation analytics leader, has launched the aviation industry’s first Airline Routes tool to identify actual flights flown by aircraft type.

It uses applied analytics to derive routes flown by airlines based on satellite-based flight tracking and fuses this with advanced fleet data.

The new premium Routes tool is part of Ascend Profiles, a visual descriptive analytics tool which enables businesses to quickly view aircraft intelligence by airline or lessor.

Businesses such as aircraft lessors, banks or aircraft manufacturers are empowered to identify the aircraft flown by route for 1,700 airlines and factor development opportunities or risk into their decision making.

By leveraging satellite-based flight tracking data the tool identifies what routes and aircraft airlines actually flew rather than what they planned to fly providing the most accurate flight completion picture.

Kevin Hightower, Cirium VP of Product said: “The Airline Routes tool is the first of its kind to bring together such advanced data – the satellite-based flight tracking and the comprehensive fleet data – meaning businesses can conduct quick yet accurate due diligence on an airline portfolio.

“Understanding which aircraft an airline is actually flying and on what routes is critical to identify where aircraft demand may be and whether an airline is growing or reducing their network.”

India is one of the markets in the spotlight currently, as air travel is helping to boost economic growth in the region. Low-cost-carrier, IndiGo recently announced it was looking to grow its international network and further solidify its domestic operations.

According to Ascend Profiles, IndiGo has a fleet of 306 aircraft – (273 in service and 33 in storage), plus 501 on order. Of the delivered fleet, 36% are on operating lease.

The Routes tool shows which two-way international routes IndiGo was operating this January which it was not in January 2022. For example, 172 flights were tracked on the newly added route between Indira-Gandhi International Airport in Delhi to Tribhuvan International in Kathmandu. All operated using Airbus A320s.

Additionally, the new tool shows the bi-directional routes for which IndiGo has ramped up operations. The carrier saw the most significant growth on the Singapore – Bengaluru route, where it completed 62 flights, all using A320s, this January versus only one flight, using an A321, last January.

IndiGo also substantially increased its operations this year on the Dubai – Ahmedabad route, completing five times the number of flights in Jan 23 when compared with Jan 22.

The Airline Routes tool is part of Ascend Profiles which visualizes aircraft intelligence of airline or lessor profiles and provides quick and accurate insights showing the latest 12-month year-over-year flights flown by an airline’s routes and can be viewed by flights, seats and ASKs. The tool is available as a web-app on desktop, tablet, and mobile. Find out more.

Notes to editors

About Cirium

Cirium brings together powerful data and analytics to keep the world moving. Delivering insight, built from decades of experience in the sector, enabling travel companies, aircraft manufacturers, airports, airlines and financial institutions, among others, to make logical and informed decisions which shape the future of travel, growing revenues and enhancing customer experiences. Cirium is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. The shares of RELX PLC are traded on the London, Amsterdam and New York Stock Exchanges using the following ticker symbols: London: REL; Amsterdam: REN; New York: RELX.

For further information please follow Cirium updates on LinkedIn or Twitter or visit


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Guardforce Security Adopts Hytera Push-to-talk to Improve Operational Efficiency


(BUSINESS WIRE) -- Hytera Communications (SZSE: 002583), a leading global provider of professional communications technologies and solutions, has been providing Guardforce Security Thailand with its newest Push-to-Talk over Cellular (PoC) radios and Hytera HyTalk software suite to facilitate nationwide instant group communications and better team collaboration among Guardforce staff.

Guardforce Thailand is a major security company that supplies technology-driven security solutions to a wide range of clients across Thailand, including banks, government organizations, retailers, shopping malls, hotels, airports, and enterprises. It currently employs approximately 5,000 security personnel nationwide across its three divisions.

The security provider used to rely on analog two-way radios for communications and found that the limitations of the legacy radio system had a detrimental effect on the efficiency of day-to-day operations. Guardforce, therefore, decided to upgrade to a new communications system with more extensive coverage, greater capacity, and better audio quality.

Guardforce chose Hytera’s PoC solution after extensive research. The one-stop solution, comprising Hytera’s HyTalk platform and PNC380 and PNC360S PoC radios, provides substantial improvements in both connectivity and functionality and serves as the choice of Guardforce moving forward in a competitive security market.

“Our staff is now equipped with Hytera PNC380 and PNC360S PoC radios that allow us to communicate over long distances,” said Kanayos Manaakkarakul, Sale and Innovation Manager of Guardforce. “I would say, these PoC radios have solved many problems for us. They helped our security personnel meet customer requirements with much higher efficiency.”

The partnership between Guardforce and Hytera will lead to more innovations for Guardforce to better serve its clients.

About Hytera

Hytera Communications Corporation Limited (SZSE: 002583) is a leading global provider of professional communications technologies and solutions. With voice, video, and data capabilities, we provide faster, safer, and more versatile connectivity for business and mission-critical users. We make the world more efficient and safer by enabling our customers to achieve more in both daily operations and emergency response. Learn more at


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Jia Liu
Hytera Communications Corporation Limited


European Society of Anaesthesiology and Intensive Care (ESAIC) Recommends Noninvasive, Continuous Hemoglobin Monitoring

Technologies Like Masimo SpHb® Offer a “Practical Approach” to Perioperative Blood Management and “Timely Detection of Changes”

(BUSINESS WIRE) -- Masimo (NASDAQ: MASI) today announced that updated guidelines published by the European Society of Anaesthesiology and Intensive Care (ESAIC) highlight the value of noninvasive, continuous hemoglobin (Hb) monitoring in helping clinicians manage perioperative bleeding. Referencing studies using technologies such as Masimo SpHb®, the guidelines note that “the use of noninvasive Hb-monitoring methods may be a practical approach to monitor[ing] the Hb concentration continuously and without accumulating additional blood losses.”1

Noting that in this area of care it is “essential to remain informed by the latest evidence,” the ESAIC, which has pledged to revisit its perioperative blood management guidelines at least every five years, has just published its updated findings, the result of a systematic review of research published from 2015 to 2021. Noting that managing bleeding during surgery is complex and “involves multiple assessment tools and strategies to ensure optimal patient care,” the guidelines cover numerous modalities, disciplines, scenarios, and patient populations – including how noninvasive, continuous hemoglobin monitoring offers a valuable way to improve blood management.

In the updated guidelines, the ESAIC notes a major drawback to measuring hemoglobin during surgery using blood gas analyzers and invasive blood sampling: “single measurements taken at different time points may not depict accurate values.” In addition, they note, excess blood sampling can lead to iatrogenic blood loss and hospital-acquired anemia. While noninvasive hemoglobin monitoring is not intended to replace invasive blood sampling, it may offer a “practical approach to monitor[ing] the Hb concentration continuously and without accumulating additional blood losses.” The guidelines also note its value “for trend analysis and to monitor changes in addition to laboratory-measured Hb concentrations during the intervals between invasive blood sampling and Hb measurements.” The guidelines continue, “Having access to continuous measurements of Hb concentrations offers timely detection of changes in Hb concentrations and adjustment, if necessary, in the clinical setting.”

In their summary of the guidance derived from their systematic literature review, the guidelines also note that when severe bleeding and volume shifts are expected or occurring, “continuous noninvasive haemoglobin monitoring may be considered for trend analyses and for reducing blood sampling for invasive laboratory measurement of haemoglobin concentration, especially in children.”

Launched in 2008, Masimo SpHb is part of the rainbow® Pulse CO-Oximetry platform, available on a variety of Masimo Pulse CO-Oximeters® and on devices from numerous third-party manufacturers, including Draeger, GE, Philips, and ZOLL. Utilizing multiple wavelengths of light, SpHb provides real-time, continuous visibility to changes in the hemoglobin trend between invasive blood samples. As part of patient blood management programs, SpHb has been found to improve outcomes in both high- and low-blood loss surgeries, such as reducing the percentage of patients receiving allogeneic transfusions,2,3 reducing the units of red blood cells transfused per patient,4-6 reducing the time to transfusion,7 reducing costs,8 and even reducing mortality 30 and 90 days after surgery by 33% and 29%, respectively (when combined with a goal-directed fluid therapy algorithm using Masimo PVi®).9 The evidence of SpHb’s impact on outcomes spans the globe, now representing 7 countries on 4 different continents.2-10 Today, Masimo SpHb technology supports clinicians and patient care in more than 75 countries.

Professor Kai Zacharowski, past President of ESAIC and senior author of the guidelines, commented, “Noninvasive hemoglobin measurements now represent standard of care in many clinical scenarios. With their inclusion in the latest perioperative bleeding guidelines, we hope that more anesthesiologists around the world incorporate this technology into their daily practice to help improve overall patient blood management.”

Professor Edoardo De Robertis, current President of ESAIC and co-author of the guidelines, noted, “The ESAIC holds the most prominent position in the community of anaesthesiologists and intensivists in Europe and elsewhere. We are pleased to share the updated guidelines with the goal of improving patient outcomes by focusing on the quality of care and patient safety strategies. Noninvasive hemoglobin monitoring has an important role throughout the perioperative period and in acute care, as it can provide trend data for more informed decision making. We look forward to seeing it adopted more widely for better patient care.”

Dr. William C. Wilson, Chief Medical Officer, Masimo, added, “With laboratory measurements, and even with bedside point-of-care hemoglobin testing, results are intermittent, sampling errors can occur, and performing these tests can be distracting during complex cases and while caring for critically ill patients. SpHb monitoring provides real-time visibility to hemoglobin levels throughout the continuum of care and has the advantages of trend analysis as well as reductions in workload and delay, enabling clinicians to adjust blood management and observe results simultaneously.”

Joe Kiani, Founder and CEO of Masimo, said, “Since its introduction 15 years ago, we’ve been heartened to see more and more clinicians around the world adopt SpHb as their standard of care, more and more clinical studies demonstrate its utility, and more and more esteemed organizations like ESAIC recognize the benefits of noninvasive hemoglobin monitoring. The result of years of development and continued refinement, powered by our expertise in advanced signal processing techniques, SpHb plays a critical role in our mission to improve patient outcomes, reduce the cost of care, and ultimately, improve life.”

SpHb is not intended to replace laboratory blood testing. Clinical decisions regarding red blood cell transfusions should be based on the clinician’s judgment considering, among other factors, patient condition, continuous SpHb monitoring, and laboratory diagnostic tests using blood samples.

@Masimo | #Masimo

About Masimo

Masimo (NASDAQ: MASI) is a global medical technology company that develops and produces a wide array of industry-leading monitoring technologies, including innovative measurements, sensors, patient monitors, and automation and connectivity solutions. In addition, Masimo Consumer Audio is home to eight legendary audio brands, including Bowers & Wilkins, Denon, Marantz, and Polk Audio. Our mission is to improve life, improve patient outcomes, and reduce the cost of care. Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry, introduced in 1995, has been shown in over 100 independent and objective studies to outperform other pulse oximetry technologies.11 Masimo SET® has also been shown to help clinicians reduce severe retinopathy of prematurity in neonates,12 improve CCHD screening in newborns,13 and, when used for continuous monitoring with Masimo Patient SafetyNet™ in post-surgical wards, reduce rapid response team activations, ICU transfers, and costs.14-17 Masimo SET® is estimated to be used on more than 200 million patients in leading hospitals and other healthcare settings around the world,18 and is the primary pulse oximetry at 9 of the top 10 hospitals as ranked in the 2022-23 U.S. News and World Report Best Hospitals Honor Roll.19 In 2005, Masimo introduced rainbow® Pulse CO-Oximetry technology, allowing noninvasive and continuous monitoring of blood constituents that previously could only be measured invasively, including total hemoglobin (SpHb®), oxygen content (SpOC™), carboxyhemoglobin (SpCO®), methemoglobin (SpMet®), Pleth Variability Index (PVi®), RPVi™ (rainbow® PVi), and Oxygen Reserve Index (ORi™). In 2013, Masimo introduced the Root® Patient Monitoring and Connectivity Platform, built from the ground up to be as flexible and expandable as possible to facilitate the addition of other Masimo and third-party monitoring technologies; key Masimo additions include Next Generation SedLine® Brain Function Monitoring, O3® Regional Oximetry, and ISA™ Capnography with NomoLine® sampling lines. Masimo’s family of continuous and spot-check monitoring Pulse CO-Oximeters® includes devices designed for use in a variety of clinical and non-clinical scenarios, including tetherless, wearable technology, such as Radius-7®, Radius PPG®, and Radius VSM™, portable devices like Rad-67®, fingertip pulse oximeters like MightySat® Rx, and devices available for use both in the hospital and at home, such as Rad-97®. Masimo hospital and home automation and connectivity solutions are centered around the Masimo Hospital Automation™ platform, and include Iris® Gateway, iSirona™, Patient SafetyNet, Replica®, Halo ION®, UniView®, UniView :60™, and Masimo SafetyNet®. Its growing portfolio of health and wellness solutions includes Radius Tº® and the Masimo W1™ watch. Additional information about Masimo and its products may be found at Published clinical studies on Masimo products can be found at

ORi, RPVi, and Radius VSM have not received FDA 510(k) clearance and are not available for sale in the United States. The use of the trademark Patient SafetyNet is under license from University HealthSystem Consortium.


  1. Kietaibl S et al. Management of severe peri-operative bleeding: Guidelines from the European Society of Anaesthesiology and Intensive Care. Eur J Anaesthesiol 2023; 40:226-304.

  2. Ehrenfeld JM et al. Continuous Non-invasive Hemoglobin Monitoring during Orthopedic Surgery: A Randomized Trial. J Blood Disorders Transf. 2014. 5:9. 2.

  3. Nakamori E et al. Geriatr Orthop Surg Rehabil. 2021 Nov 19;12:21514593211060575.

  4. Awada WN et al. Continuous and noninvasive hemoglobin monitoring reduces red blood cell transfusion during neurosurgery: a prospective cohort study. J Clin Monit Comput. 2015 Feb 4.

  5. Merolle L, Marraccini C, Di Bartolomeo E, Montella M, Pertinhez T, Baricchi R, Bonini A. Postoperative patient blood management: transfusion appropriateness in cancer patients. Blood Transfus 2020; 18: 359-65 DOI 10.2450/2020.0048-20.

  6. Saracoglu A, Abdullayez R, Sakar M, Sacak B, Incekoy F, Aykac Z. Continuous hemoglobin measurement during frontal advancement operations can improve patient outcomes. J Clin Mon Comp. 7 Mar 2022.

  7. Kamal AM et al. The Value of Continuous Noninvasive Hemoglobin Monitoring in Intraoperative Blood Transfusion Practice During Abdominal Cancer Surgery. Open J Anesth. 2016;13-19.

  8. Ribed-Sánchez B et al. Economic Analysis of the Reduction of Blood Transfusions during Surgical Procedures While Continuous Hemoglobin Monitoring is Used. Sensors. 2018, 18, 1367; doi:10.3390/s18051367.

  9. Cros J et al. Continuous hemoglobin and plethysmography variability index monitoring can modify blood transfusion practice and is associated with lower mortality. J Clin Monit Comp. 3 Aug 2019.

  10. Akdag S, Zengin SU, Cakmak G, Umuroglu T, Aykac ZZ, Saracoglu A. Targeted Bleeding Management Guided by Non-Invasive Haemoglobin Measurement in Surgical Patients. J Coll Physicians Surg Pak 2022; 32(10):1242-1248.

  11. Published clinical studies on pulse oximetry and the benefits of Masimo SET® can be found on our website at Comparative studies include independent and objective studies which are comprised of abstracts presented at scientific meetings and peer-reviewed journal articles.

  12. Castillo A et al. Prevention of Retinopathy of Prematurity in Preterm Infants through Changes in Clinical Practice and SpO2 Technology. Acta Paediatr. 2011 Feb;100(2):188-92.

  13. de-Wahl Granelli A et al. Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39,821 newborns. BMJ. 2009;Jan 8;338.

  14. Taenzer A et al. Impact of pulse oximetry surveillance on rescue events and intensive care unit transfers: a before-and-after concurrence study. Anesthesiology. 2010:112(2):282-287.

  15. Taenzer A et al. Postoperative Monitoring – The Dartmouth Experience. Anesthesia Patient Safety Foundation Newsletter. Spring-Summer 2012.

  16. McGrath S et al. Surveillance Monitoring Management for General Care Units: Strategy, Design, and Implementation. The Joint Commission Journal on Quality and Patient Safety. 2016 Jul;42(7):293-302.

  17. McGrath S et al. Inpatient Respiratory Arrest Associated With Sedative and Analgesic Medications: Impact of Continuous Monitoring on Patient Mortality and Severe Morbidity. J Patient Saf. 2020 14 Mar. DOI: 10.1097/PTS.0000000000000696.

  18. Estimate: Masimo data on file.


Forward-Looking Statements

This press release includes forward-looking statements as defined in Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, in connection with the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, among others, statements regarding the potential effectiveness of Masimo SpHb® and rainbow®. These forward-looking statements are based on current expectations about future events affecting us and are subject to risks and uncertainties, all of which are difficult to predict and many of which are beyond our control and could cause our actual results to differ materially and adversely from those expressed in our forward-looking statements as a result of various risk factors, including, but not limited to: risks related to our assumptions regarding the repeatability of clinical results; risks related to our belief that Masimo's unique noninvasive measurement technologies, including Masimo SpHb and rainbow®, contribute to positive clinical outcomes and patient safety; risks related to our belief that Masimo noninvasive medical breakthroughs provide cost-effective solutions and unique advantages; risks related to COVID-19; as well as other factors discussed in the "Risk Factors" section of our most recent reports filed with the Securities and Exchange Commission ("SEC"), which may be obtained for free at the SEC's website at Although we believe that the expectations reflected in our forward-looking statements are reasonable, we do not know whether our expectations will prove correct. All forward-looking statements included in this press release are expressly qualified in their entirety by the foregoing cautionary statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these statements or the "Risk Factors" contained in our most recent reports filed with the SEC, whether as a result of new information, future events or otherwise, except as may be required under the applicable securities laws.





Evan Lamb

Thales Launches World’s First GSMA Certified iSIM (Integrated SIM) with Qualcomm’s latest Snapdragon Mobile Platform

The launch of the world’s first security certified iSIM by the GSMA (global association for the mobile communications industry) by Thales and Qualcomm will enable smartphones to offer a space-saving approach for flexible - remotely updatable - mobile connectivity.
The integrated SIM form factor is highly attractive to device makers looking to create compact and cost-efficient smartphones, as well as other connected devices such as tablets and wearables.
Global iSIM shipments predicted to reach 300 million1 by 2027 and intended to complement SIM & eSIM market offer.

(BUSINESS WIRE) -- Leading industry innovators, Thales and Qualcomm Technologies, Inc., announce the certification of the world’s first commercially deployable iSIM (Integrated SIM) on the Snapdragon 8 Gen 2 Mobile Platform, enabling the functionality of a SIM within a smartphone’s main processor. Such GSMA’s security certification2 confirms the iSIM supports the same high standards of cyber-protection and flexible ‘anytime anywhere’ connectivity offered by the latest generation of embedded SIMs (eSIMs).

The new iSIM can now offer device makers further opportunities to save space, reduce build and supply chain costs while maintaining best-in-class security level.

Just like Thales’ eSIM, the new iSIM is fully compliant with the GSMA Remote SIM Provisioning standard; meaning its subscriptions are remotely manageable through any standard platforms.

The emerging iSIM form factor complements existing SIM and eSIM designs, and research suggests the market share to grow to 300 million by 2027, representing 19% of all eSIM shipments, according to Kaleido Intelligence.

Guillaume Lafaix, Vice President Embedded Products at Thales Mobile and Connectivity Solutions said: “The world’s first security certification of an iSIM by the GSMA follows several years of intense development work by Qualcomm Technologies and Thales. Alongside the increasingly popular eSIM, the Thales 5G iSIM gives device makers and mobile operators even greater freedom to offer their customers effortless over-the-air connectivity, and more exciting and accessible product designs.”

“We are very pleased to see our investment in high assurance processor hardware security, in collaboration with Thales, achieving the security and functional bar required by the GSMA for Remote Provisioning UICC use case. We believe a Tamper Resistant Element integrated within the host processor can efficiently enable innovative use cases across many markets and product segments,” said Ziad Asghar, Senior Vice President of Product Management, Qualcomm Technologies, Inc.

Alex Sinclair, GSMA Chief Technology Officer adds, “The GSMA is committed to promoting a ‘security-first’ culture across the entire mobile ecosystem to ensure the benefits of mobile connectivity can be enjoyed safely by all. The GSMA eUICC Security Assurance scheme ensures that eSIM products, whether integrated or discrete, have the highest possible level of security resilience. In addition, we are delighted that our processes enable faster time to market for manufacturers and allows new type of products like the integrated SIM to emerge. iSIM increases the opportunity to proliferate cellular capability and satisfies a wider and more diverse market.”

Learn more about iSIM.

About Thales

Thales (Euronext Paris: HO) is a global leader in advanced technologies, investing in digital and “deep tech” innovations — connectivity, big data, artificial intelligence, cybersecurity and quantum computing — to build a future we can all trust, which is vital to the development of our societies.

The company provides solutions, services and products that help its customers —businesses, organisations and states — in the defence, aeronautics, space, transportation and digital identity and security markets to fulfil their critical missions, by placing humans at the heart of the decision-making process.

Thales has 81,000 employees in 68 countries. In 2021, the Group generated sales of €16.2 billion

About Qualcomm

Qualcomm is enabling a world where everyone and everything can be intelligently connected. Our one technology roadmap allows us to efficiently scale the technologies that launched the mobile revolution – including advanced connectivity, high-performance, low-power compute, on-device intelligence and more – to the next generation of connected smart devices across industries. Innovations from Qualcomm and our family of Snapdragon platforms will help enable cloud-edge convergence, transform industries, accelerate the digital economy, and revolutionize how we experience the world, for the greater good.

Qualcomm Incorporated includes our licensing business, QTL, and the vast majority of our patent portfolio. Qualcomm Technologies, Inc., a subsidiary of Qualcomm Incorporated, operates, along with its subsidiaries, substantially all of our engineering, research and development functions, and substantially all of our products and services businesses, including our QCT semiconductor business. Snapdragon and Qualcomm branded products are products of Qualcomm Technologies, Inc. and/or its subsidiaries. Qualcomm patented technologies are licensed by Qualcomm Incorporated.

Snapdragon is a product of Qualcomm Technologies, Inc. and/or its subsidiaries. Snapdragon is a trademark or registered trademark of Qualcomm Incorporated.


Thales Group
Digital Identity & Security

1 Kaleido Intelligence, “eSIM Market Outlook Report 2022”,19%25%20of%20total%20eSIM%20shipments.
2 GSMA eUICC Security Assurance certification.


Thales, Media Relations
Digital Identity and Security
Vanessa Viala
+33 (0)6 07 34 00 34

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